The majority of oral pills get absorbed in the gastrointestinal tract and is transported through the liver. Liver diseases can influence bupropion half-life. Several factors have an impact on the length of time bupropion stays in the system, such as liver Impairment, renal diseases, major depressive disorder, pharmacokinetic interaction, and hydroxyl radical reactions. Factors That Dictate Wellbutrin Half-Life Period Overall, Wellbutrin SR half-life has an average half-life of about 14 hours at the terminal phase, and it can stay as long as 24 hours in the body system. Sometimes, the half-life of these metabolites can even be prolonged depending on the formulation.
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